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Sibutramine (si bue' tra meen) is actually a beta-phenylethylamine that inhibits the synaptic reuptake of both serotonin and norepinephrine. made at first being an antidepressant, it had minor impact on melancholy, but its use was linked to weightloss that appeared to be on account of decreased urge for food and lessened caloric intake. Sibutramine